Bed bugs and possible transmission of human pathogens: a systematic review.
Published in Archives of Dermatological Research
Sirtuins in dermatology: applications for future research and therapeutics
Published in Archives of Dermatological Research
Sirtuins are a family of seven proteins in humans (SIRT1–SIRT7) that are involved in multiple cellular processes relevant to dermatology. The role of sirtuins in other organ systems is established. However, the importance of these proteins in dermatology is less defined. Recently, sirtuins gained international attention because of their role as “lo...
NADPH oxidase enzymes in skin fibrosis: molecular targets and therapeutic agents
Published in Archives of Dermatological Research
Fibrosis is characterized by the excessive deposition of extracellular matrix components eventually resulting in organ dysfunction and failure. In dermatology, fibrosis is the hallmark component of many skin diseases, including systemic sclerosis, graft-versus-host disease, hypertrophic scars, keloids, nephrogenic systemic fibrosis, porphyria cutan...
The role of microRNAs in skin fibrosis.
Published in Archives of Dermatological Research
Fibrotic skin disorders may be debilitating and impair quality of life. There are few effective treatment options for cutaneous fibrotic diseases. In this review, we discuss our current understanding of the role of microRNAs (miRNAs) in skin fibrosis. miRNAs are a class of small, non-coding RNAs involved in skin fibrosis. These small RNAs range fro...
Targeting the PD-1 pathway: a promising future for the treatment of melanoma
Published in Archives of Dermatological Research
Advanced melanoma presents a significant therapeutic challenge to clinicians. Many therapies for metastatic melanoma are limited by low response rates, severe toxicities, and/or relatively short response duration. Cancer immunotherapies that act as immune-checkpoint inhibitors to block the localized immune suppression mechanisms utilized by tumors ...
Optical coherence tomography (OCT) of collagen in normal skin and skin fibrosis
Published in Archives of Dermatological Research
Optical coherence tomography (OCT) is a non-invasive imaging modality that is transforming clinical diagnosis in dermatology and other medical fields. OCT provides a cross-sectional evaluation of the epidermis and dermis and allows in vivo imaging of skin collagen. Upregulated collagen content is a key feature of fibrotic skin diseases. These disea...
